About
Titles
Susan Dwight Bliss Professor of Biostatistics; Director, Center for Methods in Implementation and Prevention Science (CMIPS); Professor of Statistics and Data Science; Professor of Medicine (Cardiovascular Medicine); Assistant Director, Global Oncology, Yale Cancer Center; Affiliated Faculty, Yale I
Biography
Donna Spiegelman was appointed the Susan Dwight Bliss Professor of Biostatistics at the Yale School of Public Health in 2018; she is also Professor of Statistics and Data Science at Yale University.
Dr. Spiegelman founded and directs the Yale Center for Methods in Implementation and Prevention Science (CMIPS) and she also leads the Global Oncology program at Yale Cancer Center.
As one of the few people in the world with a joint doctorate in biostatistics and epidemiology, she can freely speak the languages of both disciplines and switches between these two professional cultures, playing the role of interlocutor for each. She is interested in problems arising in epidemiology that require resolution, at least in part, through biostatistics.
The emerging field of implementation science is among Dr. Spiegelman's major areas of interest. This field examines barriers to the implementation of evidence-based interventions, as well as the factors that facilitate uptake of these tools. She founded CMIPS to develop tools for implementation science as well as to further the field's deployment to improve public health. The Center comprises 4 tenure-track full-time faculty members in biostatistics, social science and health economics; many additional faculty at YSPH and YSM; and PhD students, post-doctoral fellows, and master's degree students.
With colleagues at CMIPS, she studies the design and conduct of implementation studies and pragmatic trials. Topics include stepped-wedge and cluster randomized trials; positive spillover effects; two-stage designs; causal inference for large-scale public health interventions, including causal mediation analysis; correction for biases related to non-adherence and measurement error; and external generalizability; among others. CMIPS also focuses on developing methodsfor learning health care systems.
One of CMIPS' primary goals is to develop new statistical methods for implementation science. One such innovation is the Learn as You Go (LAGO) design, which allows researchers to repeatedly adapt ongoing trials in response to new trial data. Such designs help to prevent “failed trials." They can also optimize combination treatment regimens and inform cost-effective health promotion programs. Other biostatistical methods Dr. Spiegelman has developed relate to a wide range of topics, including meta-analysis, measurement error and misclassification, gene-environment and other interactions, smoothing, study design, and population-attributable risk.
Before coming to Yale, she served as professor, mentor, and expert statistician at the Harvard T.H. Chan School of Public Health for nearly 30 years.
Appointments
Biostatistics
Professor
Primary
Biostatistics
Other Departments & Organizations
- Biostatistics
- Cancer Prevention and Control
- Center for Interdisciplinary Research on AIDS
- Center for Methods in Implementation and Prevention Science (CMIPS)
- Global Mental Health Promotion Program
- Maternal and Child Health Promotion (MCHP) Program
- Yale Cancer Center
- Yale Institute for Global Health
- Yale School of Public Health
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
- YSPH Global Health Concentration
Education & Training
- ScD
- Harvard School of Public Health, Biostatistics and Epidemiology (1989)
- MS
- Harvard School of Public Health, Biostatistics (1985)
- BA
- Brandeis University, Psychology (1977)
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Research
Overview
Cancer epidemiology and prevention; Prevention science; cardiovascular disease epidemiology and prevention; HIV/AIDS epidemiology and prevention; maternal and child health promotion; mental health promotion;
Medical Subject Headings (MeSH)
Biostatistics; Cardiovascular Diseases; Clinical Trial; Epidemiologic Methods; Global Health; Health Plan Implementation; HIV Infections; Implementation Science; Maternal Mortality; Obesity
ORCID
0000-0003-4006-4650Center for Methods in Implementation and Prevention Science
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Donna Spiegelman's published research.
Publications Timeline
A big-picture view of Donna Spiegelman's research output by year.
Research Interests
Research topics Donna Spiegelman is interested in exploring.
Archana Shrestha, PhD
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Fan Li, PhD
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Sten H. Vermund, MD, PhD
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Melinda Irwin, PhD, MPH
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Raul U. Hernandez-Ramirez, PhD
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Brenda Cartmel, PhD
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506Publications
51,435Citations
HIV Infections
8 YSPH Researchers
View 79 Related Publications
Cardiovascular Diseases
5 YSPH Researchers
View 20 Related Publications
Obesity
10 YSPH Researchers
View 18 Related Publications
Epidemiologic Methods
11 YSPH Researchers
View 9 Related Publications
Implementation Science
8 YSPH Researchers
View 3 Related Publications
Global Health
45 YSPH Researchers
View 2 Related Publications
Publications
2024
Exposure measurement error in air pollution health effect studies: A pooled analysis of personal exposure validation studies across the US
Zhang B, Eum K, Szpiro A, Zhang N, Hernández Ramírez R, Spiegelman D, Suh H. Exposure measurement error in air pollution health effect studies: A pooled analysis of personal exposure validation studies across the US. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0981.
Peer-Reviewed Original Research
Concepts
Demonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol
Chebet J, Akyoo W, Goymann H, Harling G, Barnhart D, Mosha I, Kamori D, Gandhi M, Mbunda T, Kipeleka J, Sando D, Spiegelman D, Mpembeni R, Bärnighausen T. Demonstrating service delivery models for effective initiation and retention on pre-exposure prophylaxis (PrEP) among female bar workers in Dar es Salaam, Tanzania: A double randomized intervention study protocol. PLOS ONE 2024, 19: e0304077. PMID: 38935796, PMCID: PMC11210872, DOI: 10.1371/journal.pone.0304077.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Navigating grey areas in HIV and mental health implementation science
Harkness A, Giusto A, Hamilton A, Hernandez‐Ramirez R, Spiegelman D, Weiner B, Beidas R, Larson M, Lippman S, Wainberg M, Smith J. Navigating grey areas in HIV and mental health implementation science. Journal Of The International AIDS Society 2024, 27: e26271. PMID: 38923301, PMCID: PMC11197965, DOI: 10.1002/jia2.26271.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
Assessing Direct and Spillover Effects of Intervention Packages in Network-randomized Studies
Buchanan A, Hernández-Ramírez R, Lok J, Vermund S, Friedman S, Forastiere L, Spiegelman D. Assessing Direct and Spillover Effects of Intervention Packages in Network-randomized Studies. Epidemiology 2024, 35: 481-488. PMID: 38709023, DOI: 10.1097/ede.0000000000001742.
Peer-Reviewed Original Research
Concepts
Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace
Shrestha A, Tamrakar D, Ghinanju B, Shrestha D, Khadka P, Adhikari B, Shrestha J, Waiwa S, Pyakurel P, Bhandari N, Karmacharya B, Shrestha A, Shrestha R, Bhatta R, Malik V, Mattei J, Spiegelman D. Effects of a dietary intervention on cardiometabolic risk and food consumption in a workplace. PLOS ONE 2024, 19: e0301826. PMID: 38656951, PMCID: PMC11042715, DOI: 10.1371/journal.pone.0301826.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
Barriers and Facilitators of Implementing a Healthy Lifestyle Intervention at Workplaces in South Africa
Singh S, Naicker A, Grobbelaar H, Singh E, Spiegelman D, Shrestha A. Barriers and Facilitators of Implementing a Healthy Lifestyle Intervention at Workplaces in South Africa. International Journal Of Environmental Research And Public Health 2024, 21: 389. PMID: 38673303, PMCID: PMC11050208, DOI: 10.3390/ijerph21040389.
Peer-Reviewed Original Research
Concepts
Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.
Peer-Reviewed Original Research
Citations
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Concepts
Causal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure
Tang W, Spiegelman D, Liao X, Wang M. Causal Selection of Covariates in Regression Calibration for Mismeasured Continuous Exposure. Epidemiology 2024, 35: 320-328. PMID: 38630507, DOI: 10.1097/ede.0000000000001706.
Peer-Reviewed Original Research
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MeSH Keywords and Concepts
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.
Peer-Reviewed Original Research
Citations
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Concepts
Overall, Direct, Spillover, and Composite Effects of Components of a Peer-Driven Intervention Package on Injection Risk Behavior Among People Who Inject Drugs in the HPTN 037 Study
Hernández-Ramírez R, Spiegelman D, Lok J, Forastiere L, Friedman S, Latkin C, Vermund S, Buchanan A. Overall, Direct, Spillover, and Composite Effects of Components of a Peer-Driven Intervention Package on Injection Risk Behavior Among People Who Inject Drugs in the HPTN 037 Study. AIDS And Behavior 2023, 28: 225-237. PMID: 37932493, PMCID: PMC11062514, DOI: 10.1007/s10461-023-04213-x.
Peer-Reviewed Original Research
Citations
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Concepts
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Academic Achievements and Community Involvement
activity Member
CommitteesDean's Committee on Endowed Chairs
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activity Co-Chair
CommitteesPublic Health Working Group, Dean's Advisory Council for LGBTQIA+ Affairs
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activity Director
Professional OrganizationsCenter for Methods on Implementation and Prevention Science, YSPH
inaugural directorship, and director of ImpSci PhD and MS pathways, BIS
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activity Co-Director
Professional OrganizationsGlobal Oncology Program, Yale Cancer Center
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activity Member
Peer Review Groups and Grant Study SectionsCancer Prevention and Control (CPC) Research Group, Yale Cancer Center
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News
January 01, 2024
Spiegelman recognized as top female scientist for second consecutive yearRead moreabout Spiegelman recognized as top female scientist for second consecutive year
November 20, 2023
A New Approach for Evaluating Public Health InterventionsRead moreabout A New Approach for Evaluating Public Health Interventions
October 12, 2023
CMIPS faculty participate in the First Pearl River Implementation Science International Symposium (PRISIS)Read moreabout CMIPS faculty participate in the First Pearl River Implementation Science International Symposium (PRISIS)
March 08, 2023
Faculty Network Spotlight: NGNRead moreabout Faculty Network Spotlight: NGN
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Get In Touch
Contacts
donna.spiegelman@yale.edu
Mailing Address
Yale University
60 College St
New Haven, CT 06510
United States
Administrative Support
- Eleni Pettas MersiadisProgram Manager